Targeted inactivation of francisella tularensis genes by group II introns.
about
Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primatesEvasion of IFN-γ signaling by Francisella novicida is dependent upon Francisella outer membrane protein CA targetron system for gene targeting in thermophiles and its application in Clostridium thermocellumGroup II intron-based gene targeting reactions in eukaryotes.EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting.Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages.Identification and characterization of novel and potent transcription promoters of Francisella tularensis.Group II intron-anchored gene deletion in ClostridiumProtein tyrosine O-glycosylation--a rather unexplored prokaryotic glycosylation system.Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence.Utilization of an unstable plasmid and the I-SceI endonuclease to generate routine markerless deletion mutants in Francisella tularensis.Tryptophan prototrophy contributes to Francisella tularensis evasion of gamma interferon-mediated host defense.Role of pathogenicity determinant protein C (PdpC) in determining the virulence of the Francisella tularensis subspecies tularensis SCHU.Advances in genetic manipulation of obligate intracellular bacterial pathogensGenerating Isogenic Deletions (Knockouts) in Francisella tularensis, a Highly-infectious and Fastidious Gram-negative Bacterium.A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC.Pullulanase Is Necessary for the Efficient Intracellular Growth of Francisella tularensis.Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages.Improved shuttle vectors for Francisella tularensis genetics.Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge.Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis.Bacterial cellular engineering by genome editing and gene silencingGenetic manipulation of francisella tularensis.Contribution of methionine sulfoxide reductase B (MsrB) to Francisella tularensis infection in mice.Detection of Francisella tularensis and analysis of bacterial growth in ticks in Japan.Cooperation of both, the FKBP_N-like and the DSBA-like, domains is necessary for the correct function of FTS_1067 protein involved in Francisella tularensis virulence and pathogenesis.Single-copy chromosomal integration systems for Francisella tularensisTargeted gene disruption in Francisella tularensis by group II introns.Characterization of stable, constitutively expressed, chromosomal green and red fluorescent transcriptional fusions in the select agent bacterium, Francisella tularensis Schu S4 and the surrogate type B live vaccine strain (LVS).Evaluation of Francisella tularensis ΔpdpC as a candidate live attenuated vaccine against respiratory challenge by a virulent SCHU P9 strain of Francisella tularensis in a C57BL/6J mouse model.HU protein is involved in intracellular growth and full virulence of Francisella tularensis.Francisella tularensis D-Ala D-Ala Carboxypeptidase DacD Is Involved in Intracellular Replication and It Is Necessary for Bacterial Cell Wall Integrity.
P2860
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P2860
Targeted inactivation of francisella tularensis genes by group II introns.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Targeted inactivation of francisella tularensis genes by group II introns.
@en
type
label
Targeted inactivation of francisella tularensis genes by group II introns.
@en
prefLabel
Targeted inactivation of francisella tularensis genes by group II introns.
@en
P2093
P2860
P356
P1476
Targeted inactivation of francisella tularensis genes by group II introns.
@en
P2093
Bernard P Arulanandam
Greg Davis
Jieh-Juen Yu
Karl E Klose
Stephen A Rodriguez
P2860
P304
P356
10.1128/AEM.02905-07
P407
P577
2008-02-29T00:00:00Z