HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
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Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaquesImpaired antibody response causes persistence of prototypic T cell-contained virusNew concepts in HIV-1 vaccine developmentCD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationshipsInhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressorsA DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responsesEfficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trialImmune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine.HIV-1 Vaccine Trials: Evolving Concepts and DesignsCD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisMagnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical statusHost HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans.Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequencesPerforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replicationHuman leukocyte antigen class I supertypes and HIV-1 control in African Americans.Mucosal T-cell responses to HIV: responding at the front linesFrequency of long-term nonprogressors in HIV-1 seroconverters From Rakai UgandaQuantifying the impact of human immunodeficiency virus-1 escape from cytotoxic T-lymphocytes.Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers.A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllersA low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic ControllersImpaired replication capacity of acute/early viruses in persons who become HIV controllers.A correlate of HIV-1 control consisting of both innate and adaptive immune parameters best predicts viral load by multivariable analysis in HIV-1 infected viremic controllers and chronically-infected non-controllersComparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers.Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers.HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responsesNatural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells.Development of skewed functionality of HIV-1-specific cytotoxic CD8(+) T cells from primary to early chronic phase of HIV infection.HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatmentLiving in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIV
P2860
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P2860
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
HLA class I-restricted T-cell ...... y for long-term virus control.
@en
type
label
HLA class I-restricted T-cell ...... y for long-term virus control.
@en
prefLabel
HLA class I-restricted T-cell ...... y for long-term virus control.
@en
P2093
P2860
P356
P1433
P1476
HLA class I-restricted T-cell ...... y for long-term virus control.
@en
P2093
April Ferre
Barbara Shacklett
Brinda Emu
Elizabeth Sinclair
Hiroyu Hatano
J M McCune
Jeffrey N Martin
P2860
P304
P356
10.1128/JVI.02176-07
P407
P577
2008-03-19T00:00:00Z