High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies.
about
Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationSomatic hypermutation maintains antibody thermodynamic stability during affinity maturationProtein stability and dynamics modulation: the case of human frataxinCDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.Frontier of therapeutic antibody discovery: The challenges and how to face them.Rapid optimization and prototyping for therapeutic antibody-like molecules.Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress.Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering.Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinityAggregation and chemical modification of monoclonal antibodies under upstream processing conditions.
P2860
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P2860
High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
High-throughput measurement, c ...... f Pfizer-generated antibodies.
@en
type
label
High-throughput measurement, c ...... f Pfizer-generated antibodies.
@en
prefLabel
High-throughput measurement, c ...... f Pfizer-generated antibodies.
@en
P2093
P2860
P356
P1433
P1476
High-throughput measurement, c ...... f Pfizer-generated antibodies.
@en
P2093
Amy C King
Davinder Gill
Mark R H Krebs
Matthew Woods
Zhijian Lu
P2860
P304
P356
10.1002/PRO.680
P577
2011-07-13T00:00:00Z