Loss of Geminin induces rereplication in the presence of functional p53 - Wikidata - awgldk - TriplyDB

Loss of Geminin induces rereplication in the presence of functional p53

Loss of Geminin induces rereplication in the presence of functional p53

http://www.wikidata.org/entity/Q24676493

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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint Disruption of mechanisms that prevent rereplication triggers a DNA damage response Geminin regulates neuronal differentiation by antagonizing Brg1 activity The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Regulation of replication licensing by acetyltransferase Hbo1.Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis Prevention of DNA re-replication in eukaryotic cells Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity Replication licensing and cancer--a fatal entanglement?Selective killing of cancer cells by suppression of geminin activity Preventing re-replication of chromosomal DNA.Functional domains of the Xenopus replication licensing factor Cdt1 Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts The Non-Canonical Role of Aurora-A in DNA Replication Genomic instability in cancer.Re-replication of a centromere induces chromosomal instability and aneuploidy The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Replication fork instability and the consequences of fork collisions from rereplication CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination Cellular checkpoint mechanisms monitoring proper initiation of DNA replication Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication.The APC/C inhibitor, Emi1, is essential for prevention of rereplication APC/C--the master controller of origin licensing?ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.DDB1 maintains genome integrity through regulation of Cdt1 The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.Checkpoint effects and telomere amplification during DNA re-replication in fission yeast.Cdk2 is required for p53-independent G2/M checkpoint control.

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P2860

Loss of Geminin induces rereplication in the presence of functional p53

http://www.wikidata.org/entity/Q24676493

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Loss of Geminin induces rereplication in the presence of functional p53

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Loss of Geminin induces rereplication in the presence of functional p53

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Loss of Geminin induces rereplication in the presence of functional p53

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type

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Loss of Geminin induces rereplication in the presence of functional p53

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Loss of Geminin induces rereplication in the presence of functional p53

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Loss of Geminin induces rereplication in the presence of functional p53

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prefLabel

Loss of Geminin induces rereplication in the presence of functional p53

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Loss of Geminin induces rereplication in the presence of functional p53

@en

Loss of Geminin induces rereplication in the presence of functional p53

@nl

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Loss of Geminin induces rereplication in the presence of functional p53

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Andrea Ballabeni

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Laura Masiero

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Marina Melixetian

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Raffaella Zamponi

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P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

The DNA damage response: putting checkpoints in perspective

DNA replication in eukaryotic cells

Regulation of chromosome replication

Distinct roles for cyclins E and A during DNA replication complex assembly and activation

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10.1083/JCB.200403106

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4

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165

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Patrizia Gasparini

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2004-05-24T00:00:00Z

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