Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2 - Wikidata - awgldk - TriplyDB

Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2

Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2

http://www.wikidata.org/entity/Q38702252

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Mechanism of Platinum Derivatives Induced Kidney Injury Mechanisms of Cisplatin nephrotoxicity miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs Esters of Bendamustine Are by Far More Potent Cytotoxic Agents than the Parent Compound against Human Sarcoma and Carcinoma Cells Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury.Immunohistochemical localization of OCT2 in the cochlea of various species.Membrane transporters as mediators of Cisplatin effects and side effects.Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.Role of the copper transporter, CTR1, in platinum-induced ototoxicity.Carboplatin instead of cisplatin in combination with dexamethasone, high-dose cytarabine with or without rituximab (DHAC+/-R) is an effective treatment with low toxicity in Hodgkin's and non-Hodgkin's lymphomas.Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2).Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection.Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Pathophysiology of cisplatin-induced acute kidney injury.Ototoxic Model of Oxaliplatin and Protection from Nicotinamide Adenine Dinucleotide Drug-induced impairment of renal function.Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS.The association of transporter genes polymorphisms and lung cancer chemotherapy response Gender difference in Cisplatin-induced nephrotoxicity in a rat model.EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer Cisplatin ototoxicity in rat cochlear organotypic cultures.Effects of a DPP4 inhibitor on cisplatin-induced acute kidney injury: study protocol for a randomized controlled trial.Molecular mechanisms of resistance and toxicity associated with platinating agents.Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.Contribution of tumoral and host solute carriers to clinical drug response.Influence of Oct1/Oct2-deficiency on cisplatin-induced changes in urinary N-acetyl-beta-D-glucosaminidase.Drug-drug interactions involving membrane transporters in the human kidney.A Comprehensive Review on the Genetic Regulation of Cisplatin-induced Nephrotoxicity Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment.Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation.Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters.Amniotic Fluid-Derived Mesenchymal Stem Cells Cut Short the Acuteness of Cisplatin-Induced Nephrotoxicity in Sprague-Dawley Rats The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity.Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.Organic cation transporters are determinants of oxaliplatin cytotoxicity.Generation of kidney organoids from human pluripotent stem cells

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Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2

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The American Journal of Pathology

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Cisplatin nephrotoxicity is cr ...... n organic cation transporter 2

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Detlef Lang

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Eberhard Schlatter

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Hans-Jürgen Piechota

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Hermann Koepsell

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Hermann Pavenstädt

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Jochen Zisowsky

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Jörg Haier

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Thomas Ludwig

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Ulrich Jaehde

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Cloning and characterization of two human polyspecific organic cation transporters

Properties and regulation of organic cation transport in freshly isolated human proximal tubules

Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases

Membrane localization of the electrogenic cation transporter rOCT1 in rat liver

Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.

Cisplatin pharmacokinetics and its nephrotoxicity in diabetic rabbits.

Gene expression levels and immunolocalization of organic ion transporters in the human kidney.

Organic cation transporters.

Cisplatin and platinum drugs at the molecular level. (Review).

Molecular and cellular physiology of renal organic cation and anion transport.

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6

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Giuliano Ciarimboli

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