Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold.

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Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold.

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Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold.

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Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold.

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P1476

Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold

@en

P2093

Dongdong Tong

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Fenghe Zhang

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Jing Sun

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Qian Zhang

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Yongtao Wang

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P2860

Signaling by target of rapamycin proteins in cell growth control

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase

Discovery and SAR of spirochromane Akt inhibitors

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases

American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy.

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer.

Akt inhibitors in clinical development for the treatment of cancer.

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.

Current overview of the role of Akt in cancer studies via applied immunohistochemistry.

P304

791-803

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P31

scholarly article

P356

10.1111/CBDD.13000

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Guisen Zhao

Dezhi Yang

P577

2017-05-07T00:00:00Z

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P698

28390089

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