Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase - Wikidata - awgldk - TriplyDB

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase

http://www.wikidata.org/entity/Q27652216

about

Discovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)The critical role of Akt in cardiovascular function The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects Impact of metal binding on the antitumor activity and cellular imaging of a metal chelator cationic imidazopyridine derivative.Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies.Chemical interrogation of the malaria kinome.A kinase-independent function of AKT promotes cancer cell survival.Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways.Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing.Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway The UPR inducer DPP23 inhibits the metastatic potential of MDA-MB-231 human breast cancer cells by targeting the Akt-IKK-NF-κB-MMP-9 axis.AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival.Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer.Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.New inhibitors of the mammalian target of rapamycin signaling pathway for cancer.Personalized therapies in the cancer "omics" era Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives.A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA.Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold.Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors.Inhibitor hijacking of Akt activation.Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer.Synthesis and evaluation of indazole based analog sensitive Akt inhibitors Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.Effect of AKT inhibition on epithelial-mesenchymal transition and ZEB1-potentiated radiotherapy in nasopharyngeal carcinoma.PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses.

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P2860

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase

http://www.wikidata.org/entity/Q27652216

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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type

label

Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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prefLabel

Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

@en

Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

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Journal of Medicinal Chemistry

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Identification of 4-(2-(4-amin ...... novel inhibitor of AKT kinase

@en

P2093

Anthony E Choudhry

http://www.w3.org/2001/XMLSchema#string

Dennis S Yamashita

http://www.w3.org/2001/XMLSchema#string

Dennis T Takata

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Derek Eberwein

http://www.w3.org/2001/XMLSchema#string

Derek R Duckett

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Dirk A Heerding

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Edgar R Wood

http://www.w3.org/2001/XMLSchema#string

Elisabeth A Minthorn

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Gregory L Warren

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Igor G Safonov

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5663-79

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scholarly article

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2893216

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10.1021/JM8004527

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18

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51

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2008-09-25T00:00:00Z

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18800763

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