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High quality, small molecule-activity datasets for kinase researchCancer Transcriptome Dataset Analysis: Comparing Methods of Pathway and Gene Regulatory Network-Based Cluster Identification.Tissue-specific tumorigenesis: context matters.RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.Kinase inhibitors as potential agents in the treatment of multiple myeloma.Understanding cell signaling in cancer stem cells for targeted therapy - can phosphoproteomics help to reveal the secrets?PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection.Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines.A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin.Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.Harnessing the power of proteomics for identification of oncogenic, druggable signalling pathways in cancer.Measuring Kinase Activity-A Global Challenge.Optochemical Control of Biological Processes in Cells and Animals.Advances of small molecule targeting of kinases.Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours.Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome.TrkC promotes colorectal cancer growth and metastasis.Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer.Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression.Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach.Protein Kinase Targets in Breast Cancer.Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies.The pseudokinases SgK269 and SgK223: A novel oncogenic alliance in human cancer.Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes.Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.A whole-animal platform to advance a clinical kinase inhibitor into new disease space.Recognition of sites of functional specialisation in all known eukaryotic protein kinase families.MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery.Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma.In Vivo Phosphoproteome Analysis Reveals Kinome Reprogramming in Hepatocellular Carcinoma.Hierarchical Organization Endows the Kinase Domain with Regulatory PlasticityComputational Structural Biology of -nitrosylation of Cancer Targets
P2860
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P2860
description
2016 nî lūn-bûn
@nan
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
name
The kinome 'at large' in cancer.
@en
type
label
The kinome 'at large' in cancer.
@en
prefLabel
The kinome 'at large' in cancer.
@en
P2860
P50
P356
P1476
The kinome 'at large' in cancer.
@en
P2093
Luxi Zhang
P2860
P2888
P356
10.1038/NRC.2015.18
P407
P577
2016-01-01T00:00:00Z
P6179
1042959126