Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts.
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αv integrins: key regulators of tissue fibrosisGenome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies.Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient miceScleroderma, fibroblasts, signaling, and excessive extracellular matrix.Molecular and cellular mechanisms of pulmonary fibrosis.The impact of Fli1 deficiency on the pathogenesis of systemic sclerosisA novel cell adhesion region in tropoelastin mediates attachment to integrin αVβ5.Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.Future treatments in systemic sclerosis.Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.The lens as a model for fibrotic disease.Integrin-mediated regulation of TGFβ in fibrosisEpigenetics and systemic sclerosis.Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts.Recent advances in animal models of systemic sclerosis.Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli-1-knockout mice by increasing Fli-1 DNA binding ability.Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis.Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1.Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma.Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.Differential effects of the immunosuppressant FK-506 on human alpha2(I) collagen gene expression and transforming growth factor beta signaling in normal and scleroderma fibroblasts.Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation.Contribution of the α8 integrin chain to the expression of extracellular matrix components.Constitutive activation of c-Abl/protein kinase C-δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma.Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective alpha(v)beta (5) integrin ligand.Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate.Recent advances in the treatment of skin involvement in systemic sclerosis.A cell adhesive peptide from tropoelastin promotes sequential cell attachment and spreading via distinct receptors.Exon-1 polymorphism of ctla-4 gene is not associated with systemic sclerosis in Iranian patients
P2860
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P2860
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts.
@en
type
label
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts.
@en
prefLabel
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts.
@en
P2093
P2860
P1476
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts.
@en
P2093
Hironobu Ihn
Kenichi Yamane
Kunihiko Tamaki
Masahide Kubo
Yoshihide Asano
P2860
P304
P356
10.1016/S0002-9440(10)63215-4
P407
P577
2004-04-01T00:00:00Z