Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
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8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsStructural analysis of human KDM5B guides histone demethylase inhibitor developmentAssessing histone demethylase inhibitors in cells: lessons learned.Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse CompoundsInhibitors of Protein Methyltransferases and Demethylases.Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitutionAutochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.Small molecule KDM4s inhibitors as anti-cancer agents.
P2860
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P2860
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Cell Penetrant Inhibitors of t ...... rimidin-4(3H)-one Derivatives.
@en
type
label
Cell Penetrant Inhibitors of t ...... rimidin-4(3H)-one Derivatives.
@en
prefLabel
Cell Penetrant Inhibitors of t ...... rimidin-4(3H)-one Derivatives.
@en
P2093
P1476
Cell Penetrant Inhibitors of t ...... rimidin-4(3H)-one Derivatives.
@en
P2093
Alex G S Preston
Carl Haslam
Chun-wa Chung
David M Wilson
Fiona Brown
Gail A Seal
Gerard Joberty
Inma Rioja
Jack A Brown
Joanna Taylor
P304
P356
10.1021/ACS.JMEDCHEM.5B01538
P407
P577
2016-01-15T00:00:00Z