about
Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinineStructure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the LeishmaniasesCommunication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide SynthaseStructure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1Recognition of the DNA minor groove by thiazotropsin analoguesThe Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS HitsStructurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment ScreeningA divergent synthesis of minor groove binders with tail group variation.Diversity oriented syntheses of fused pyrimidines designed as potential antifolates.Ranking ligand affinity for the DNA minor groove by experiment and simulation.Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy propertiesDesigning anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.Minor groove binders as anti-infective agents.Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasomeDrug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosusFrom multiply active natural product to candidate drug? Antibacterial (and other) minor groove binders for DNA.The diversity-oriented synthesis of pteridines - achievements and potential for development.DNA sequence recognition by an isopropyl substituted thiazole polyamide.Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups.Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.2,2,2-Trifluoro-N-(isoquinolin-5-ylmeth-yl)acetamide.Crystal structure of N,N-dimethyl-2-[(4-methyl-benz-yl)sulfon-yl]ethanamine.In situ detection of pterins by SERS.Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove.Syntheses of highly functionalised 6-substituted pteridines.A prototype solid phase synthesis of pteridines and related heterocyclic compounds.Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.Synthesis and antimicrobial activity of some netropsin analogues.6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases.A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11.M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.DNA binding of a short lexitropsin.Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and BenzothiazolesAsymmetric Rhodium-Catalysed Addition of Arylboronic Acids to Acyclic Unsaturated Esters Containing a Basic γ-Amino GroupA Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and BenzoxazolesAmide isosteres in structure-activity studies of antibacterial minor groove bindersTetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator propertiesA detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation
P50
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P50
description
hulumtues
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wetenschapper
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հետազոտող
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J. Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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Colin J Suckling
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P106
P21
P31
P4012
P496
0000-0003-4515-5498