about
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signalingExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.A Novel Thyrotropin-Releasing Hormone Receptor Missense Mutation (P81R) in Central Congenital Hypothyroidism.Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation.Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond networkModulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop.Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis.Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.Dysregulation of betaglycan expression in primary human endometrial carcinomas.The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormonesHuman Gain-of-Function MC4R Variants Show Signaling Bias and Protect against ObesityIdentification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonismExpression of endoglin in primary endometrial cancerAn aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jacek Mokrosinski
@ast
Jacek Mokrosinski
@en
Jacek Mokrosinski
@es
Jacek Mokrosinski
@nl
Jacek Mokrosinski
@sl
type
label
Jacek Mokrosinski
@ast
Jacek Mokrosinski
@en
Jacek Mokrosinski
@es
Jacek Mokrosinski
@nl
Jacek Mokrosinski
@sl
prefLabel
Jacek Mokrosinski
@ast
Jacek Mokrosinski
@en
Jacek Mokrosinski
@es
Jacek Mokrosinski
@nl
Jacek Mokrosinski
@sl
P106
P1153
17135635100
P21
P31
P496
0000-0001-5008-0457