Impact of Glycosylation on Effector Functions of Therapeutic IgG
about
High-Throughput Analysis and Automation for Glycomics StudiesConsistency of quality attributes for the glycosylated monoclonal antibody Humira® (adalimumab).Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy.Function characterization of a glyco-engineered anti-EGFR monoclonal antibody cetuximab in vitro.Comparison of originator and biosimilar therapeutic monoclonal antibodies using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry.Analysis of glycoforms on the glycosylation site and the glycans in monoclonal antibody biopharmaceuticals.Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach.Glycosylation: impact, control and improvement during therapeutic protein production.Biosimilar monoclonal antibodies: A Canadian regulatory perspective on the assessment of clinically relevant differences and indication extrapolation.LC-MS-based quantification of intact proteins: perspective for clinical and bioanalytical applications.In Response to: 'Impact of Glycosylation on Effector Functions of Therapeutic IgG' (Pharmaceuticals 2010, 3, 146-157).Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture.Abnormal galactosylation of immunoglobulin G in cerebrospinal fluid of multiple sclerosis patients.A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins.Kinetics of N-Glycan Release from Human Immunoglobulin G (IgG) by PNGase F: All Glycans Are Not Created Equal.Online enzymatic sequencing of glycans from Trastuzumab by phospholipid-assisted capillary electrophoresis.Capillary electrophoresis coupled to electrospray mass spectrometry through a coaxial sheath flow interface and semi-permanent phospholipid coating for the determination of oligosaccharides labeled with 1-aminopyrene-3,6,8-trisulfonic acid.Profiling N-linked oligosaccharides from IgG by high-performance anion-exchange chromatography with pulsed amperometric detection.A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies.Modulation of mAb quality attributes using microliter scale fed-batch cultures.Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.IgG Glyco-Engineering to Improve IVIg Potency
P2860
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P2860
Impact of Glycosylation on Effector Functions of Therapeutic IgG
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
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2010年论文
@zh-cn
name
Impact of Glycosylation on Effector Functions of Therapeutic IgG
@en
type
label
Impact of Glycosylation on Effector Functions of Therapeutic IgG
@en
prefLabel
Impact of Glycosylation on Effector Functions of Therapeutic IgG
@en
P2860
P356
P1433
P1476
Impact of Glycosylation on Effector Functions of Therapeutic IgG
@en
P2093
Jean-Luc Teillaud
P2860
P304
P356
10.3390/PH3010146
P577
2010-01-12T00:00:00Z