Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

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β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site.

P2860

Q52574646-0ECE59E0-607C-4ABD-817C-E4D3C135D0CE

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Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

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http://www.wikidata.org/entity/Q38824056

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2016 nî lūn-bûn

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2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

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type

Item

label

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

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prefLabel

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

@en

P1476

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

@en

P2093

Dimitri Krainc

http://www.w3.org/2001/XMLSchema#string

Jianbin Zheng

http://www.w3.org/2001/XMLSchema#string

Long Chen

http://www.w3.org/2001/XMLSchema#string

Richard B Silverman

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P2860

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila

Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery.

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.

Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening.

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase.

P304

8508-8520

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scholarly article

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10.1021/ACS.JMEDCHEM.6B00930

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English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Michael Schwake

P577

2016-09-06T00:00:00Z

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P698

27598312

http://www.w3.org/2001/XMLSchema#string

P921

N-[1-(phenylmethyl)-4-piperidinyl]-2-(3-pyridinyl)-4-quinazolinamine

P932

5033727

http://www.w3.org/2001/XMLSchema#string

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

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P2860

P2860

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932