Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans. - Wikidata - awgldk - TriplyDB

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.

http://www.wikidata.org/entity/Q38827148

about

Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.PPARs and Mitochondrial Metabolism: From NAFLD to HCC.The dark side of the moon: AKT as a tumor suppressor in the liver?TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway.Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice.ORF3 as a sensitive and specific diagnostic index for hepatitis E.Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.Significance and Mechanism of Androgen Receptor (AR) Overexpression and AR-mTOR Crosstalk in Hepatocellular Carcinoma.Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway.Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis.Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cells The role of YAP/TAZ activity in cancer metabolic reprogramming Role of hepatoma-derived growth factor in promoting de novo lipogenesis and tumorigenesis in hepatocellular carcinoma

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Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.

http://www.wikidata.org/entity/Q38827148

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Inactivation of fatty acid syn ...... ven by AKT in mice and humans.

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type

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Inactivation of fatty acid syn ...... ven by AKT in mice and humans.

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Inactivation of fatty acid syn ...... ven by AKT in mice and humans.

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J.JHEP.2015.10.004

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Journal of Hepatology

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Inactivation of fatty acid syn ...... ven by AKT in mice and humans.

@en

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Christy Joseph

http://www.w3.org/2001/XMLSchema#string

Chunmei Wang

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Diego F Calvisi

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Frank Dombrowski

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Giulia M Pilo

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Lei Li

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Li Che

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Lijie Jiang

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Maria M Simile

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Marta Mela

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mTOR signaling in growth control and disease

Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.

Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.

SREBP-1 has a prognostic role and contributes to invasion and metastasis in human hepatocellular carcinoma

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity.

Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

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333-341

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10.1016/J.JHEP.2015.10.004

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2

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64

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Clay F. Semenkovich

Antonio Cigliano

Gavinella Latte

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2015-10-14T00:00:00Z

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282944194

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