Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse - Wikidata - awgldk - TriplyDB

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

http://www.wikidata.org/entity/Q34144518

about

Transposon-mediated genome manipulation in vertebrates A DNA transposon-based approach to validate oncogenic mutations in the mouse The expanding role of mouse genetics for understanding human biology and disease piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons.piggyBac transposon-mediated long-term gene expression in mice.Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites.Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis Cancer gene discovery in hepatocellular carcinoma Unexpectedly high copy number of random integration but low frequency of persistent expression of the Sleeping Beauty transposase after trans delivery in primary human T cells.Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice.In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background.Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice Functional genomics of Plasmodium falciparum through transposon-mediated mutagenesis.Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin Comparison of liver oncogenic potential among human RAS isoforms.De novo induction of genetically engineered brain tumors in mice using plasmid DNA Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans.The expanding universe of transposon technologies for gene and cell engineering.Hydrodynamic transfection for generation of novel mouse models for liver cancer research.Transgenic mouse models generated by hydrodynamic transfection for genetic studies of liver cancer and preclinical testing of anti-cancer therapy.Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.Sleeping Beauty transposition: from biology to applications.Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways.Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.Sleeping beauty transposase has an affinity for heterochromatin conformation.Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT).An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes.Integration of oncogenes via Sleeping Beauty as a mouse model of HPV16+ Oral tumor and immunologic control.A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine.

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Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

http://www.wikidata.org/entity/Q34144518

description

2005 nî lūn-bûn

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2005年の論文

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name

Somatic integration of an onco ...... tumor development in the mouse

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Somatic integration of an onco ...... tumor development in the mouse

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Somatic integration of an onco ...... tumor development in the mouse

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Somatic integration of an onco ...... tumor development in the mouse

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Somatic integration of an onco ...... tumor development in the mouse

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Somatic integration of an onco ...... tumor development in the mouse

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Proceedings of the National Academy of Sciences of the United States of America

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Somatic integration of an onco ...... tumor development in the mouse

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Corey M Carlson

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David A Largaespada

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Joel L Frandsen

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Nicole Kirchhof

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R Scott McIvor

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P2860

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells

Regulated transposition of a fish transposon in the mouse germ line

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

Transcription start regions in the human genome are favored targets for MLV integration

Transposition and gene disruption in the male germline of the mouse.

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells

Development of a flexible and specific gene delivery system for production of murine tumor models.

High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice.

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