Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.

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Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping.

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Q47344295-C924DE47-3713-49EC-B01F-0E53BCECFAB8

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Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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Interaction between NUDT15 and ...... acute lymphoblastic leukemia.

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Interaction between NUDT15 and ...... acute lymphoblastic leukemia.

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Interaction between NUDT15 and ...... acute lymphoblastic leukemia.

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P1476

Interaction between NUDT15 and ...... acute lymphoblastic leukemia.

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P2860

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.

Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients.

Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.

P2888

tpj.2017.12

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scholarly article

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10.1038/TPJ.2017.12

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2017-04-18T00:00:00Z

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1084904738

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P921

mercaptopurine

Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.

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P2860

P2860

Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.

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