Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
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Cannabinoid receptor type-1: breaking the dogmasCannabidiol as a Potential New Type of an Antipsychotic. A Critical Review of the EvidenceInteractions of Cannabinoids With Biochemical SubstratesNovel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s).Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders.Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis.ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in miceMolecular Targets of the Phytocannabinoids: A Complex Picture.Cannabidiol protects an in vitro model of the blood-brain barrier from oxygen-glucose deprivation via PPARγ and 5-HT1A receptors.In silico mapping of allosteric ligand binding sites in type-1 cannabinoid receptor.Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation.Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture.Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease.Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.Phytocannabinoids: a unified critical inventory.Is there a role for cannabidiol in psychiatry?Molecular Pharmacology of Phytocannabinoids.The endocannabinoid system as a target for novel anxiolytic drugs.Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.Characteristics and Treatment of Patients with Clinical Illness Due to Synthetic Cannabinoid Inhalation Reported by Medical Toxicologists: A ToxIC Database Study.A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans.Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia?Δ9-Tetrahydrocannabinol decreases willingness to exert cognitive effort in male rats.Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention.Cannabis and Cannabinoids for Chronic Pain.Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors.Cannabinoid receptor signalingChronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment.Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells.Assessing Allosteric Modulation of CB1 at the Receptor and Cellular Levels.Cannabidiol reduces ethanol consumption, motivation and relapse in mice.Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential.Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol.Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats.
P2860
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P2860
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
@en
type
label
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
@en
prefLabel
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
@en
P2093
P2860
P921
P356
P1476
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
@en
P2093
A M Bagher
E M Denovan-Wright
M E M Kelly
R B Laprairie
P2860
P304
P356
10.1111/BPH.13250
P407
P577
2015-07-27T00:00:00Z