The core spliceosome as target and effector of non-canonical ATM signalling.
about
The RNA Splicing Response to DNA DamageATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorTranscription Blockage Leads to New BeginningsDefective control of pre-messenger RNA splicing in human diseaseInhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingRUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeastUbiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life spanEpigenome Maintenance in Response to DNA DamageXRN2 Links Transcription Termination to DNA Damage and Replication Stress.Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion IrradiationThe spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency.RNA splicing factors as oncoproteins and tumour suppressors.hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes.Historical perspective on the DNA damage response.Human Ribonuclease H1 resolves R loops and thereby enables progression of the DNA replication fork.The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.RNA Processing and Genome Stability: Cause and Consequence.Pharmacology of Modulators of Alternative Splicing.Sources and consequences of oxidative damage from mitochondria and neurotransmitter signaling.NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair.Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.The Effects of LW-AFC on the Hippocampal Transcriptome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease.Splicing factor gene mutations in hematologic malignancies.Replication Fork Protection Factors Controlling R-Loop Bypass and SuppressionEmerging roles for histone modifications in DNA excision repair.Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage.C9orf72 expansion disrupts ATM-mediated chromosomal break repair.Chromatin modifiers and remodellers in DNA repair and signalling.Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans.R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters.RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate.
P2860
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P2860
The core spliceosome as target and effector of non-canonical ATM signalling.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
@zh-hant
name
The core spliceosome as target and effector of non-canonical ATM signalling.
@en
type
label
The core spliceosome as target and effector of non-canonical ATM signalling.
@en
prefLabel
The core spliceosome as target and effector of non-canonical ATM signalling.
@en
P2093
P2860
P50
P356
P1433
P1476
The core spliceosome as target and effector of non-canonical ATM signalling
@en
P2093
Frank G Grosveld
Jan H J Hoeijmakers
Leon H F Mullenders
Loes Snijder
Maria Tresini
Mischa G Vrouwe
Wim Vermeulen
P2860
P2888
P356
10.1038/NATURE14512
P407
P50
P577
2015-06-24T00:00:00Z
P5875
P6179
1009856991