GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. - Wikidata - awgldk - TriplyDB

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

http://www.wikidata.org/entity/Q38895410

about

Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis Targeting BET bromodomain proteins in solid tumors BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells.Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Expression of Rab5a correlates with tumor progression in pancreatic carcinoma.Bromodomain and extraterminal protein inhibitors in pediatrics: A review of the literature.Bromodomain inhibitors and cancer therapy: From structures to applications.BET Bromodomain Proteins as Cancer Therapeutic Targets.Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy.Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells.Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2.The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling.Rab11a sustains GSK3β/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer.The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine.Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells

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GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.

http://www.wikidata.org/entity/Q38895410

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

@wuu

2015年学术文章

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2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

@zh

2015年學術文章

@zh-hant

name

GLI2-dependent c-MYC upregulat ...... BET bromodomain inhibitor JQ1.

@en

type

label

GLI2-dependent c-MYC upregulat ...... BET bromodomain inhibitor JQ1.

@en

prefLabel

GLI2-dependent c-MYC upregulat ...... BET bromodomain inhibitor JQ1.

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Scientific Reports

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GLI2-dependent c-MYC upregulat ...... BET bromodomain inhibitor JQ1

@en

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Benjamin Kwok

http://www.w3.org/2001/XMLSchema#string

David J Bentrem

http://www.w3.org/2001/XMLSchema#string

Hidayatullah G Munshi

http://www.w3.org/2001/XMLSchema#string

Jonathan D Licht

http://www.w3.org/2001/XMLSchema#string

Kazumi Ebine

http://www.w3.org/2001/XMLSchema#string

Krishan Kumar

http://www.w3.org/2001/XMLSchema#string

Lawrence M Knab

http://www.w3.org/2001/XMLSchema#string

Relja Popovic

http://www.w3.org/2001/XMLSchema#string

Sania S Raza

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P2860

Selective inhibition of BET bromodomains

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Epithelial-mesenchymal transitions in development and disease

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

The epigenomics of cancer

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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9489

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scholarly article

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10.1038/SREP09489

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5

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Christina R Chow

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2015-03-25T00:00:00Z

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274090810

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1046032603

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25807524

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4452877

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