Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.
about
Contemporary murine models in preclinical astrocytoma drug developmentAn Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery.Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model.Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models.Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition
P2860
Q27026937-7FE34E56-490E-41B0-84F9-1BE275D83FDAQ36119941-5246AE1B-DF87-44AF-8E80-E2E21D03D166Q36977690-61E9ED4F-6742-4178-8A92-87C477B5BF79Q38764607-93EBD481-DF4E-4C11-BEB4-3E31439E00A6Q48229251-DB371A46-9B47-44DC-AF17-10E04EE7ACD5Q49375023-7172985F-9863-4F5F-84D9-9268A260EF35Q50444863-1E1F1AC8-90BD-4815-B98B-A9C1EC67803FQ57640954-58CAD068-54E1-4DBA-82D4-5DCF7B7BB9E0
P2860
Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Modeling astrocytoma pathogene ...... , genetically engineered mice.
@en
type
label
Modeling astrocytoma pathogene ...... , genetically engineered mice.
@en
prefLabel
Modeling astrocytoma pathogene ...... , genetically engineered mice.
@en
P2093
P2860
P356
P1476
Modeling astrocytoma pathogene ...... , genetically engineered mice.
@en
P2093
Andrea M Werneke
Brian H Constance
Byron Huff
Kristen K White
Mark Vitucci
Robert S McNeill
Ryan E Bash
P2860
P304
P356
10.3791/51763
P577
2014-08-12T00:00:00Z