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DrugCentral: online drug compendiumHarnessing public domain data to discover and validate therapeutic targets.Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.'Big data' approaches for novel anti-cancer drug discovery.A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor.Pharos: Collating protein information to shed light on the druggable genome.Drug repurposing screens and synergistic drug-combinations for infectious diseases.TIN-X: target importance and novelty explorer.A Bright Future for Serial Femtosecond Crystallography with XFELs.Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.A resource of potential drug targets and strategic decision-making for obstructive sleep apnoea pharmacotherapy.The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin.A simple mathematical approach to the analysis of polypharmacology and polyspecificity data.Logic Modeling in Quantitative Systems Pharmacology.Opportunities for therapeutic antibodies directed at G-protein-coupled receptors.From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns.Structural and Functional View of Polypharmacology.Models of Models: A Translational Route for Cancer Treatment and Drug Development.Accelerating Patients' Access to Advanced Therapies in the EU.Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor.In vivo validation of metastasis-regulating microRNA-766 in human triple-negative breast cancer cells.Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson's Disease: Rationale for Clinical Trial, and Current Progress.DDR: Efficient computational method to predict drug-target interactions using graph mining and machine learning approaches.ECOdrug: a database connecting drugs and conservation of their targets across species.Drug target ontology to classify and integrate drug discovery data.Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms.Drug Repurposing for the Treatment of Acute Myeloid Leukemia.Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics.Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.GPCRs as targets for approved drugs: How many targets and how many drugs?Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.Biased signalling: from simple switches to allosteric microprocessors.Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases.Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.Comparative Proteomic Analysis of the Effect of Periplocoside P from Periploca sepium on Brush Border Membrane Vesicles in Midgut Epithelium of Mythimna separata Larvae.Pharmacogenomics of GPCR Drug Targets.Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.
P2860
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P2860
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
A comprehensive map of molecular drug targets.
@en
A comprehensive map of molecular drug targets.
@nl
type
label
A comprehensive map of molecular drug targets.
@en
A comprehensive map of molecular drug targets.
@nl
prefLabel
A comprehensive map of molecular drug targets.
@en
A comprehensive map of molecular drug targets.
@nl
P2093
P50
P356
P1476
A comprehensive map of molecular drug targets
@en
P2093
A Patrícia Bento
Anneli Karlsson
Bissan Al-Lazikani
Cristian G Bologa
Ramesh S Donadi
Tudor I Oprea
P2888
P356
10.1038/NRD.2016.230
P577
2016-12-02T00:00:00Z
P6179
1030835959