Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles Predicting Off-Target Binding Profiles With Confidence Using Conformal Prediction

P2860

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Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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Item

label

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

@en

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

@en

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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P1476

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

@en

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PREDICT: a method for inferring novel drug indications with application to personalized medicine

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurements

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors

Prediction of drug-target interactions and drug repositioning via network-based inference

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

ASDCD: antifungal synergistic drug combination database

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179-192

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scholarly article

review article

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10.1080/17460441.2018.1413089

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English

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http://www.w3.org/2001/XMLSchema#string

P478

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Tero Aittokallio

Balaguru Ravikumar

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2017-12-12T00:00:00Z

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P698

29233023

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Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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P2860

P2860

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery.

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P1433

P1476

P2860

P304

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P1433

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P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698