about
Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacyDiscovery of potent pteridine reductase inhibitors to guide antiparasite drug developmentStructural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitorsThe structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolismTargeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid DerivativeAlanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1Structure-based design of inhibitors specific for bacterial thymidylate synthaseStructure-based studies on species-specific inhibition of thymidylate synthasePhthalein derivatives as a new tool for selectivity in thymidylate synthase inhibitionPermeation through the cell membrane of a boron-based β-lactamase inhibitor.Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activityTranslational repression of thymidylate synthase by targeting its mRNA.Thymidylate synthase structure, function and implication in drug discovery.Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family.Homodimeric enzymes as drug targets.Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.The inhibition of extended spectrum β-lactamases: hits and leads.Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells.Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides.2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells.Biochemical effects of riluzole on Leishmania parasites.Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines.Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case.Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines.Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transferStructure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell cultureHotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]-benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity.The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Maria Paola Costi
@ast
Maria Paola Costi
@en
Maria Paola Costi
@es
Maria Paola Costi
@nl
Maria Paola Costi
@sl
type
label
Maria Paola Costi
@ast
Maria Paola Costi
@en
Maria Paola Costi
@es
Maria Paola Costi
@nl
Maria Paola Costi
@sl
prefLabel
Maria Paola Costi
@ast
Maria Paola Costi
@en
Maria Paola Costi
@es
Maria Paola Costi
@nl
Maria Paola Costi
@sl
P1053
F-4747-2015
P106
P1153
6603791773
P21
P31
P3829
P4012
P496
0000-0002-0443-5402