Recurrent design patterns in the feedback regulation of the mammalian signalling network.
about
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2Signalling ballet in space and timeSystematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.A new efficient approach to fit stochastic models on the basis of high-throughput experimental data using a model of IRF7 gene expression as case study.microRNA evolution in a human transcription factor and microRNA regulatory network.Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis.Mapping complex traits as a dynamic system.Discovering causal signaling pathways through gene-expression patterns.Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation.Open questions: the disrupted circuitry of the cancer cellBalancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback.Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior.Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration.Intrinsically disordered segments affect protein half-life in the cell and during evolution.A mathematical model of CR3/TLR2 crosstalk in the context of Francisella tularensis infection.Under-dominance constrains the evolution of negative autoregulation in diploids.Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes developmentDeterminants of cell-to-cell variability in protein kinase signaling.Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite.Signalling by protein phosphatases and drug development: a systems-centred view.How time delay and network design shape response patterns in biochemical negative feedback systemsRegulation of HBEGF by Micro-RNA for Survival of Developing Human Trophoblast Cells.Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.Exosomal miRs in Lung Cancer: A Mathematical Model.The whole-genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge.The interplay of cis-regulatory elements rules circadian rhythms in mouse liver.Reconstructing regulatory networks from the dynamic plasticity of gene expression by mutual informationConservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathwayNested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks.Towards a comprehensive picture of the genetic landscape of complex traits.Altered dynamics of a lipid raft associated protein in a kidney model of Fabry diseaseNetwork quantification of EGFR signaling unveils potential for targeted combination therapy.Robustness of signal transduction pathways.Consequences of feedback in signal transduction for targeted therapies.A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.An immediate-late gene expression module decodes ERK signal durationProtein synthesis rate is the predominant regulator of protein expression during differentiation.Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.
P2860
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P2860
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@en
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@nl
type
label
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@en
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@nl
prefLabel
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@en
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@nl
P2860
P50
P356
P1476
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
@en
P2093
Hanspeter Herzel
P2860
P356
10.1038/MSB.2008.29
P577
2008-05-06T00:00:00Z