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Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistabilitySmall RNAs establish delays and temporal thresholds in gene expressionUltrasensitization: switch-like regulation of cellular signaling by transcriptional inductionMulti-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior.Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes developmentDeterminants of cell-to-cell variability in protein kinase signaling.A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms.Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.Systems analysis of MAPK signal transduction.Robustness of signal transduction pathways.Identifying Novel Transcriptional Regulators with Circadian Expression.A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.Recurrent design patterns in the feedback regulation of the mammalian signalling network.Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activationAtypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.A minimal circadian clock model.Competing docking interactions can bring about bistability in the MAPK cascade.Kinetic mechanisms for overexpression insensitivity and oncogene cooperation.Quantitative analysis of ultrasensitive responses.Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR.Correlated receptor transport processes buffer single-cell heterogeneity.Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.Silence on the relevant literature and errors in implementation.A mesoscale model of G1/S phase transition in liver regeneration.Estrogen-dependent control and cell-to-cell variability of transcriptional bursting.Effects of sequestration on signal transduction cascades.Correction: Multi-Target Regulation by Small RNAs Synchronizes Gene Expression Thresholds and May Enhance Ultrasensitive Behavior
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P50
description
hulumtues
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հետազոտող
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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type
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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prefLabel
Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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Stefan Legewie
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P214
P106
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P214
P2456
P31
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0000-0003-4111-0567
P735
P7859
viaf-107092954