about
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damageChe-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoterPatient-derived xenografts: a relevant preclinical model for drug developmentIncrease of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration scheduleTelomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectStabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activitiesTRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft.AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere MaintenanceTelomerase as a new target for the treatment of hormone-refractory prostate cancer.EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceBeta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium saltsEvidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.A novel pathway links telomeres to NK-cell activity: Implications for immunotherapyMethods of studying telomere damage induced by quadruplex-ligand complexes.Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1.Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells.Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer.Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules.Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage.Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence.Antiproliferative effect of Aurora kinase targeting in mesothelioma.Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer.Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells.In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors.Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells.
P50
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P50
description
hulumtuese
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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type
label
Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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Annamaria Biroccio
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P1053
B-2861-2018
P106
P1153
6604026353
P21
P31
P3829
P496
0000-0003-3198-3532