Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability.
about
The first draft of the endostatin interaction networkPrion hypothesis: the end of the controversy?Perlecan maintains the integrity of cartilage and some basement membranesHeparan sulfate proteoglycan induces the production of NO and TNF-alpha by murine microglia.Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allelePolyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infectionAgrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchymaExpression of human liver HSPGs on acute myeloid leukemiaHeparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.Neuropathology of Alzheimer's diseaseExtracellular matrix molecules: potential targets in pharmacotherapy.Cellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo.Heparin induces harmless fibril formation in amyloidogenic W7FW14F apomyoglobin and amyloid aggregation in wild-type protein in vitro.Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's diseaseInhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.Neurovascular function in Alzheimer's disease patients and experimental models.Inhibition of amyloid A amyloidogenesis in vivo and in tissue culture by 4-deoxy analogues of peracetylated 2-acetamido-2-deoxy-alpha- and beta-d-glucose: implications for the treatment of various amyloidoses.Changes in brain β-amyloid deposition and aquaporin 4 levels in response to altered agrin expression in miceAgrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain.Amyloid accomplices and enforcersOverall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptideHeparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cellsIncreased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat dietHeat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease.Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.Neuroprotective properties of glycosaminoglycans: potential treatment for neurodegenerative disorders.Misfolding of amyloidogenic proteins and their interactions with membranes.The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy.An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways.Extracellular matrix proteomics in schizophrenia and Alzheimer's disease.The ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans.Aβ-40 Y10F increases βfibrils formation but attenuates the neurotoxicity of amyloid-β peptide.Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease.The molecular basis of memory.Lessons learned from protein aggregation: toward technological and biomedical applications.The vascular basement membrane in the healthy and pathological brain.
P2860
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P2860
Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Perlecan binds to the beta-amy ...... tains A beta fibril stability.
@en
Perlecan binds to the beta-amy ...... tains A beta fibril stability.
@nl
type
label
Perlecan binds to the beta-amy ...... tains A beta fibril stability.
@en
Perlecan binds to the beta-amy ...... tains A beta fibril stability.
@nl
prefLabel
Perlecan binds to the beta-amy ...... tains A beta fibril stability.
@en
Perlecan binds to the beta-amy ...... tains A beta fibril stability.
@nl
P2093
P1476
Perlecan binds to the beta-amy ...... ntains A beta fibril stability
@en
P2093
P304
P356
10.1046/J.1471-4159.1997.69062452.X
P407
P577
1997-12-01T00:00:00Z