Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

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Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes

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Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

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2017 nî lūn-bûn

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Charcot Marie Tooth 2B Periphe ...... utations Impact NGF Signaling?

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Chengbiao Wu

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Harry Liu

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Creative Commons Attribution

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Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes.

RILP is required for the proper morphology and function of late endosomes

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

A mechanism for retromer endosomal coat complex assembly with cargo

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

Structural basis for recruitment of RILP by small GTPase Rab7

A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene.

Genome-wide association study reveals genetic risk underlying Parkinson's disease

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scholarly article

review article

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10.3390/IJMS18020324

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English

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2017-02-04T00:00:00Z

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28165391

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Charcot–Marie–Tooth disease

peptide

transport protein

genetic variation

hereditary sensory and autonomic neuropathy type 2

nerve tissue proteins

Anzim

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5343860

http://www.w3.org/2001/XMLSchema#string

Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

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P2860

P2860

Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling?

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P1433

P1476

P2093

P275

P2860

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P356

P407

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P577

P698

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P356

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P1476

P2093

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P31

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P407

P433

P478

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P698

P921

P932