Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseA Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportLRRK2 transport is regulated by its novel interacting partner Rab32Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsUpstream deregulation of calcium signaling in Parkinson's diseaseGenetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceSynaptopathies: synaptic dysfunction in neurological disorders - A review from students to studentsLRRK2 at the interface of autophagosomes, endosomes and lysosomesThe clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brainLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainA visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.Two-Pore Channels and Parkinson's Disease: Where's the Link?Role of LRRK2 in the regulation of dopamine receptor traffickingParkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectivesThe 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.LRRK2 autophosphorylation enhances its GTPase activityComprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe.Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.The Evolution of Genetics: Alzheimer's and Parkinson's Diseases.Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Pathway for Parkinson disease.TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.Genetic, structural, and molecular insights into the function of ras of complex proteins domains.Interaction of LRRK2 with kinase and GTPase signaling cascadesLRRK2 pathobiology in Parkinson's disease.Impaired intracellular trafficking defines early Parkinson's diseaseCellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Genes associated with Parkinson's disease: regulation of autophagy and beyond.
P2860
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P248
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P2860
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Unbiased screen for interactor ...... and familial Parkinson disease
@ast
Unbiased screen for interactor ...... and familial Parkinson disease
@en
Unbiased screen for interactor ...... and familial Parkinson disease
@en-gb
Unbiased screen for interactor ...... and familial Parkinson disease
@nl
type
label
Unbiased screen for interactor ...... and familial Parkinson disease
@ast
Unbiased screen for interactor ...... and familial Parkinson disease
@en
Unbiased screen for interactor ...... and familial Parkinson disease
@en-gb
Unbiased screen for interactor ...... and familial Parkinson disease
@nl
prefLabel
Unbiased screen for interactor ...... and familial Parkinson disease
@ast
Unbiased screen for interactor ...... and familial Parkinson disease
@en
Unbiased screen for interactor ...... and familial Parkinson disease
@en-gb
Unbiased screen for interactor ...... and familial Parkinson disease
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Unbiased screen for interactor ...... and familial Parkinson disease
@en
P2093
Alexandria Beilina
Alice Kaganovich
Iakov N Rudenko
Jinhui Ding
Kelechi Ndukwe
Laura Civiero
Lois E Greene
Lorraine V Kalia
Mike A Nalls
P2860
P304
P3181
P356
10.1073/PNAS.1318306111
P407
P50
P577
2014-02-18T00:00:00Z