Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.
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The mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trialsNon-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?Notch signaling as a novel regulator of metabolismNotch activation drives adipocyte dedifferentiation and tumorigenic transformation in miceAdipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.New insight into the SSC8 genetic determination of fatty acid composition in pigs.Liver zonation: Novel aspects of its regulation and its impact on homeostasis.Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesityWhole-body and hepatic insulin resistance in obese childrenTreatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity.Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway.A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolismPathogenesis of selective insulin resistance in isolated hepatocytes.Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice.LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.The new biology of diabetes.Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation.mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.Recent Advances in Adipose mTOR Signaling and Function: Therapeutic ProspectsHepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.ChREBP regulates fructose-induced glucose production independently of insulin signaling.Therapeutic modulation of Notch signalling--are we there yet?Emerging roles of Notch signaling in liver disease.Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology.The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target?Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways.Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?Role of the Notch signaling in cholangiocarcinoma.Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations.Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.The emerging roles of Notch signaling in leukemia and stem cells.Obesity Notches up fatty liver.Notch signaling and progenitor/ductular reaction in steatohepatitis.Curcumin suppresses Notch‑1 signaling: Improvements in fatty liver and insulin resistance in rats.
P2860
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P2860
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@en
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@nl
type
label
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@en
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@nl
prefLabel
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@en
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of Notch uncouples ...... y decreasing mTorc1 stability.
@en
P2093
Henry N Ginsberg
Jan Kitajewski
Thaned Kangsamaksin
Utpal B Pajvani
P2860
P2888
P304
P356
10.1038/NM.3259
P407
P577
2013-07-07T00:00:00Z