about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesMaintaining Genome Stability in Defiance of Mitotic DNA DamageSister chromatid decatenation: bridging the gaps in our knowledgeNucleases in homologous recombination as targets for cancer therapyTopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.Replication stress: getting back on trackTumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage ResponseDNA secondary structure at chromosomal fragile sites in human disease.ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission.DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae.Potential biomarkers of DNA replication stress in cancer.Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.Causes and consequences of replication stress.Rescue from replication stress during mitosis.Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.Large transcription units unify copy number variants and common fragile sites arising under replication stressTOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damageRecombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2pPyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.Human CST abundance determines recovery from diverse forms of DNA damage and replication stress.Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.How unfinished business from S-phase affects mitosis and beyondUnreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains.Maintenance of genome stability by Fanconi anemia proteins.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.The contribution of dormant origins to genome stability: from cell biology to human genetics.DNA damage repair machinery and HIV escape from innate immune sensing.Replication fork recovery and regulation of common fragile sites stability.Updating the mechanisms of common fragile site instability: how to reconcile the different views?Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.Chromosome Dynamics during Mitosis.Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.
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description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
MUS81 promotes common fragile site expression.
@en
MUS81 promotes common fragile site expression.
@nl
type
label
MUS81 promotes common fragile site expression.
@en
MUS81 promotes common fragile site expression.
@nl
prefLabel
MUS81 promotes common fragile site expression.
@en
MUS81 promotes common fragile site expression.
@nl
P2093
P2860
P50
P356
P1433
P1476
MUS81 promotes common fragile site expression
@en
P2093
Ian D Hickson
Sheroy Minocherhomji
Songmin Ying
Theresa Wass
Wai Kit Chu
P2860
P2888
P304
P356
10.1038/NCB2773
P577
2013-06-30T00:00:00Z