KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
about
Targeting cancer using KAT inhibitors to mimic lethal knockoutsWriters, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break RepairNon-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage SignalingATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorCross talk of tyrosine kinases with the DNA damage signaling pathwaysChromatin perturbations during the DNA damage response in higher eukaryotesMetabolic modulation of chromatin: implications for DNA repair and genomic integrityCrosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repairSystemic DNA damage responses in aging and diseasesUbiquitylation, neddylation and the DNA damage responseThe acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses.Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingA fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Rational design and validation of a Tip60 histone acetyltransferase inhibitor.Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways.DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments.A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.Epigenetic memory: the Lamarckian brainThe lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.Functional characterization of the TERRA transcriptome at damaged telomeres.Activation of DNA damage response signaling by condensed chromatin.Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine.A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency.Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix.L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activationDepletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formationRole of the Exocyst Complex Component Sec6/8 in Genomic StabilityDestabilization of pluripotency in the absence of Mad2l2.Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1.Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination.Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregationReactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics ScreenThe Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins.The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair.NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9.
P2860
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P2860
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
@en
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.
@nl
type
label
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
@en
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.
@nl
prefLabel
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
@en
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.
@nl
P2860
P356
P1433
P1476
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
@en
P2860
P2888
P356
10.1038/NATURE12201
P407
P577
2013-05-26T00:00:00Z
P6179
1007782112