Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. - Wikidata - awgldk - TriplyDB

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

http://www.wikidata.org/entity/Q39150091

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The utility of transposon mutagenesis for cancer studies in the era of genome editing.A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies Epigenetic mechanisms drive the progression of neurofibromas to malignant peripheral nerve sheath tumors Simple and efficient methods for enrichment and isolation of endonuclease modified cells Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.Discovery of co-occurring driver pathways in cancer Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells.Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen.A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma.RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor.FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis.Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors.Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.Cancer gene discovery: exploiting insertional mutagenesis.Mechanism-based cancer therapy: resistance to therapy, therapy for resistance.Psychiatric disturbances regulate the innate immune system in CSF of conscious mice.Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery PVT1 dependence in cancer with MYC copy-number increase.Cancer of the Peripheral Nerve in Neurofibromatosis Type 1.Immortalization of human normal and NF1 neurofibroma Schwann cells.An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.

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Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

http://www.wikidata.org/entity/Q39150091

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Forward genetic screen for mal ...... athways driving tumorigenesis.

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Forward genetic screen for mal ...... athways driving tumorigenesis.

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type

label

Forward genetic screen for mal ...... athways driving tumorigenesis.

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Forward genetic screen for mal ...... athways driving tumorigenesis.

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prefLabel

Forward genetic screen for mal ...... athways driving tumorigenesis.

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Forward genetic screen for mal ...... athways driving tumorigenesis.

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Nature Genetics

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Forward genetic screen for mal ...... athways driving tumorigenesis.

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Aaron Sarver

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Adrienne L Watson

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Branden S Moriarity

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Christopher L Moertel

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David A Largaespada

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Dominic A Beckmann

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Eric P Rahrmann

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Kwangmin Choi

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Margaret H Collins

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Margaret R Wallace

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P2860

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

Malignant peripheral nerve sheath tumours in neurofibromatosis 1

NF1 tumor suppressor gene function: narrowing the GAP

Targeted genome editing across species using ZFNs and TALENs

The emerging roles of forkhead box (Fox) proteins in cancer

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756-766

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10.1038/NG.2641

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7

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45

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Vincent W. Keng

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2013-05-19T00:00:00Z

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236920148

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23685747

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malignant peripheral nerve sheath tumor

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3695033

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