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Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitroHigh levels of soluble syndecan-1 in myeloma-derived bone marrow: modulation of hepatocyte growth factor activityThe role of hepatocyte growth factor and its receptor c-Met in multiple myeloma and other blood malignancies.Identification of new targets for therapy of osteolytic bone disease in multiple myeloma.Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cellsBone disease in multiple myeloma.Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma.Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro.High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis.HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma.Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3.VOLIN and KJON-Two novel hyperdiploid myeloma cell lines.The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells.Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.Allelic mutations in noncoding genomic sequences construct novel transcription factor binding sites that promote gene overexpression.Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patientsDecorin is down-regulated in multiple myeloma and MGUS bone marrow plasma and inhibits HGF-induced myeloma plasma cell viability and migration.HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase.Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC.Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: implications for multiple myeloma.FGFR3 is expressed and is important for survival in INA-6, a human myeloma cell line without a t(4;14).c-Met signaling promotes IL-6-induced myeloma cell proliferation.Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1alpha.Hepatocyte growth factor promotes migration of human myeloma cells.Toll-like receptors mediate proliferation and survival of multiple myeloma cells.Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor.A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells.Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma.Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells.Interleukin-21 is a growth and survival factor for human myeloma cells.Heparan sulfate regulates targeting of syndecan-1 to a functional domain on the cell surface.Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells.Apoptosis, proliferation and NF-kappaB activation induced by agonistic Fas antibodies in the human myeloma cell line OH-2: amplification of Fas-mediated apoptosis by tumor necrosis factor.Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: a possible role for HGF in myeloma-associated osteolytic bone disease.Interleukin-15 blocks apoptosis and induces proliferation of the human myeloma cell line OH-2 and freshly isolated myeloma cells.Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice.Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines.The role of the two TNF receptors in proliferation, NF-kappa B activation and discrimination between TNF and LT alpha signalling in the human myeloma cell line OH-2.Comparison of the effects of 2-chlorodeoxyadenosine and melphalan myeloma cell lines.
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2000-01-01T00:00:00Z
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