Interleukin-21 is a growth and survival factor for human myeloma cells.
about
Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitroBiology of IL-21 and the IL-21 receptorElevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myelomaA flow cytometry technique to study intracellular signals NF-kappaB and STAT3 in peripheral blood mononuclear cells.IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts.Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays.Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domainGene expression of anti- and pro-apoptotic proteins in malignant and normal plasma cells.Novel therapeutic approaches for multiple myeloma.Ex Vivo Maintenance of Primary Human Multiple Myeloma Cells through the Optimization of the Osteoblastic Niche.Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implicationsThe molecular basis of IL-21-mediated proliferation.Targeting signalling pathways for the treatment of multiple myeloma.Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cellsTh-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis.IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitroSTAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.Immune therapies.The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptorHigh expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis.A phase I dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade B-cell lymphoproliferative disordersIL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma.Prognostic value of Th17 cells in acute leukemia.Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.Interleukin-21: a double-edged sword with therapeutic potential.Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism.IL-21: a pleiotropic cytokine with potential applications in oncology.IL-21 and T Cell Differentiation: Consider the Context.Interleukin 21 - its potential role in the therapy of B-cell lymphomas.IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration.Feasibility study: phosphospecific flow cytometry enabling rapid functional analysis of bone marrow samples from patients with multiple myeloma.c-Met signaling promotes IL-6-induced myeloma cell proliferation.Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.Associations of Autoimmunity, Immunodeficiency, Lymphomagenesis, and Gut Microbiota in Mice with Knockins for a Pathogenic Autoantibody.Targeting NF-kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth.Toll-like receptors mediate proliferation and survival of multiple myeloma cells.Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells.Mechanisms of Drug Resistance in Relapse and Refractory Multiple Myeloma.
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P2860
Interleukin-21 is a growth and survival factor for human myeloma cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Interleukin-21 is a growth and survival factor for human myeloma cells.
@en
type
label
Interleukin-21 is a growth and survival factor for human myeloma cells.
@en
prefLabel
Interleukin-21 is a growth and survival factor for human myeloma cells.
@en
P2093
P1433
P1476
Interleukin-21 is a growth and survival factor for human myeloma cells.
@en
P2093
Anders Sundan
Anders Waage
Anne-Tove Brenne
Henrik Hjorth-Hansen
P304
P356
10.1182/BLOOD.V99.10.3756
P407
P577
2002-05-01T00:00:00Z