Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

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Potential Therapeutic Applications of MnSODs and SOD-Mimetics.PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies

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Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

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Update on hypoxia-inducible fa ...... rom physiology to therapeutics

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Update on hypoxia-inducible fa ...... om physiology to therapeutics.

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Update on hypoxia-inducible fa ...... rom physiology to therapeutics

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Update on hypoxia-inducible fa ...... om physiology to therapeutics.

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Update on hypoxia-inducible fa ...... rom physiology to therapeutics

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Update on hypoxia-inducible fa ...... om physiology to therapeutics.

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P1476

Update on hypoxia-inducible fa ...... rom physiology to therapeutics

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Betty Gardie

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Florence Robriquet

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Ines Batinic-Haberle

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Jiannis Ragoussis

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Johanna Myllyharju

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Judith Vmg Bovée

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Lisa Oliver

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Peppi Koivunen

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Valérie Trichet

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Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Targeting HIF-1 for cancer therapy

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways

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11-20

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scholarly article

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10.2147/HP.S127042

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Peter J. Ratcliffe

Claire Vinatier

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2017-03-15T00:00:00Z

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28352643

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5359007

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Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

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Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

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P1476

P2093

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P356

P478

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P577

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