Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
about
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinomaEvolving concepts in cancer therapy through targeting sphingolipid metabolismSphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor MicroenvironmentCharacterization of isoenzyme-selective inhibitors of human sphingosine kinasesBiological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agentSphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 ActivationEffect of alkyl chain length on sphingosine kinase 2 selectivity.The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.Re-configuration of sphingolipid metabolism by oncogenic transformation.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.Interdiction of sphingolipid metabolism to improve standard cancer therapies.A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathwaySphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.An oncogenic role for sphingosine kinase 2.Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival.Overexpression of Sphk2 is associated with gefitinib resistance in non-small cell lung cancer.Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.Down-regulation of Sphk2 suppresses bladder cancer progression.The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies.Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain.Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers.Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.SphK2 over-expression promotes osteosarcoma cell growth.Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer.Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
P2860
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P2860
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@en
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@nl
type
label
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@en
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@nl
prefLabel
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@en
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@nl
P2860
P1476
Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
@en
P2093
Charles D Smith
P2860
P304
P356
10.1158/1541-7786.MCR-11-0336
P577
2011-09-06T00:00:00Z