Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.
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The notch ligand JAGGED1 as a target for anti-tumor therapyOvercoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune DysfunctionPrognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-AnalysisTargeting hypoxic response for cancer therapyAntioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem CellsX-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitorHypoxia-inducible factor 1 and breast cancer metastasisCarbonic anhydrase IX inhibitors in cancer therapy: an update.Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment.Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors.3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma.Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.Combination therapy in combating cancer.The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype.E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxiaExpression of hypoxic marker carbonic anhydrase IX predicts poor prognosis in resectable hepatocellular carcinoma.High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7Reprogramming during epithelial to mesenchymal transition under the control of TGFβCarbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition.Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastomaIn Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast CancerITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models.Glucose Uptake and Intracellular pH in a Mouse Model of Ductal Carcinoma In situ (DCIS) Suggests Metabolic Heterogeneity.Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients.Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies.Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells.Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells.Histopathological determinants of tumor resistance: a special look to the immunohistochemical expression of carbonic anhydrase IX in human cancers.Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases.Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors.Sulfonamides and their isosters as carbonic anhydrase inhibitors.Targeting carbonic anhydrase IX activity and expression.Designing carbonic anhydrase inhibitors for the treatment of breast cancer.Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells.Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors.Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditionsHypoxia and cellular metabolism in tumour pathophysiology.
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P2860
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Targeting carbonic anhydrase I ...... ells within the hypoxic niche.
@en
Targeting carbonic anhydrase I ...... ells within the hypoxic niche.
@nl
type
label
Targeting carbonic anhydrase I ...... ells within the hypoxic niche.
@en
Targeting carbonic anhydrase I ...... ells within the hypoxic niche.
@nl
prefLabel
Targeting carbonic anhydrase I ...... ells within the hypoxic niche.
@en
Targeting carbonic anhydrase I ...... ells within the hypoxic niche.
@nl
P2093
P2860
P356
P1433
P1476
Targeting carbonic anhydrase I ...... cells within the hypoxic niche
@en
P2093
C T Supuran
P C McDonald
S Aparicio
P2860
P2888
P304
P356
10.1038/ONC.2012.550
P407
P577
2012-12-03T00:00:00Z