LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. - Wikidata - awgldk - TriplyDB

LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.

LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.

http://www.wikidata.org/entity/Q39256587

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Evaluating biomarkers to model cancer risk post cosmic ray exposure Intestinal tumor in a dish Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer.The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cells LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells.TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway.Drug rechallenge and treatment beyond progression--implications for drug resistance.Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5.The role of microRNAs in the regulation of cancer stem cells.Epiregulin as a therapeutic target in non-small-cell lung cancer Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells.Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells.An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development.Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer.Dissecting tumour heterogeneity in flies: genetic basis of interclonal oncogenic cooperation.Application of iPS cell technology to cancer epigenome study: uncovering the mechanism of cell status conversion for drug resistance in tumor.Concise reviews: cancer stem cells: from concept to cure.LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.Understanding the colon cancer stem cells and perspectives on treatment.Cancer stem cells in human digestive tract malignancies.Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc.Generation and characterization of monoclonal antibodies against human LGR6.Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation Visualization and targeting of LGR5+ human colon cancer stem cells.Characterization of EBV-related lymphoproliferative lesions arising in donor lymphocytes of transplanted human tumor tissues in the NOG mouse.The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice.MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells.LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling.PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells.RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transition.Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment.

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P2860

LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.

http://www.wikidata.org/entity/Q39256587

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

@en

LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

@nl

type

label

LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

@en

LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

@nl

prefLabel

LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

@en

LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

@nl

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LGR5-positive colon cancer ste ...... pable of tumor reconstitution.

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Arnold J Levine

http://www.w3.org/2001/XMLSchema#string

Atsuhiko Kato

http://www.w3.org/2001/XMLSchema#string

Chie Kato

http://www.w3.org/2001/XMLSchema#string

Eri Hashimoto

http://www.w3.org/2001/XMLSchema#string

Hironori Mutoh

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Hisafumi Yamada-Okabe

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Kenji Yoshida

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Koichi Matsubara

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Masahiko Kuroda

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Masaki Yamazaki

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P2860

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines

Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

Phenotypic characterization of human colorectal cancer stem cells

Prospective identification of tumorigenic breast cancer cells

Identification and expansion of human colon-cancer-initiating cells

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Identification of human brain tumour initiating cells

Identification of stem cells in small intestine and colon by marker gene Lgr5

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

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10.1002/STEM.1257

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12

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30

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232321089

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23081779

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