LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.
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Evaluating biomarkers to model cancer risk post cosmic ray exposureIntestinal tumor in a dishKrüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cellsEstablishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cellsCD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotypeCluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoidsSerum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer.The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cellsLGR5 is required for the maintenance of spheroid-derived colon cancer stem cells.TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosisEstablishment of patient-derived cancer xenografts in immunodeficient NOG mice.The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway.Drug rechallenge and treatment beyond progression--implications for drug resistance.Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5.The role of microRNAs in the regulation of cancer stem cells.Epiregulin as a therapeutic target in non-small-cell lung cancerFocal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells.Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells.An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development.Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer.Dissecting tumour heterogeneity in flies: genetic basis of interclonal oncogenic cooperation.Application of iPS cell technology to cancer epigenome study: uncovering the mechanism of cell status conversion for drug resistance in tumor.Concise reviews: cancer stem cells: from concept to cure.LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.Understanding the colon cancer stem cells and perspectives on treatment.Cancer stem cells in human digestive tract malignancies.Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc.Generation and characterization of monoclonal antibodies against human LGR6.Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activationVisualization and targeting of LGR5+ human colon cancer stem cells.Characterization of EBV-related lymphoproliferative lesions arising in donor lymphocytes of transplanted human tumor tissues in the NOG mouse.The status of donor cancer tissues affects the fate of patient-derived colorectal cancer xenografts in NOG mice.MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells.LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling.PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells.RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transition.Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment.
P2860
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P2860
LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@en
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@nl
type
label
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@en
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@nl
prefLabel
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@en
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@nl
P2093
P2860
P356
P1433
P1476
LGR5-positive colon cancer ste ...... pable of tumor reconstitution.
@en
P2093
Arnold J Levine
Atsuhiko Kato
Eri Hashimoto
Hironori Mutoh
Hisafumi Yamada-Okabe
Kenji Yoshida
Koichi Matsubara
Masahiko Kuroda
Masaki Yamazaki
P2860
P304
P356
10.1002/STEM.1257
P577
2012-12-01T00:00:00Z