Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. - Wikidata - awgldk - TriplyDB

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.

http://www.wikidata.org/entity/Q39285948

about

Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy Connecting the Dots: From DNA Damage and Repair to Aging Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability The Mcm2-7 replicative helicase: a promising chemotherapeutic target Polymerase δ replicates both strands after homologous recombination-dependent fork restart Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness Causes and consequences of replication stress.Rescue from replication stress during mitosis.Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation.Genetic variation in human DNA replication timing Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.Folate levels modulate oncogene-induced replication stress and tumorigenicity S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas.Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.Identification of early replicating fragile sites that contribute to genome instability Replication stress and cancer: it takes two to tango.Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription.RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress.A non-redundant function of cyclin E1 in hematopoietic stem cells.Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors.Early replication fragile sites: where replication-transcription collisions cause genetic instability.Deubiquitylating enzymes and DNA damage response pathways.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Next-generation sequencing and DNA replication in human cells: the future has arrived.Mechanisms underlying mutational signatures in human cancers.Structural genomic alterations in primary mediastinal large B-cell lymphoma.Replication fork reversal in eukaryotes: from dead end to dynamic response.DNA replication stress and cancer: cause or cure?Human Ribonuclease H1 resolves R loops and thereby enables progression of the DNA replication fork.DNA replication stress: from molecular mechanisms to human disease.Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.ATR inhibition rewires cellular signaling networks induced by replication stress.Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.Oncogenes create a unique landscape of fragile sites.DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress.

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P2860

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.

http://www.wikidata.org/entity/Q39285948

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Increased replication initiati ...... E-induced replication stress.

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Increased replication initiati ...... E-induced replication stress.

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type

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Increased replication initiati ...... E-induced replication stress.

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Increased replication initiati ...... E-induced replication stress.

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Increased replication initiati ...... E-induced replication stress.

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Increased replication initiati ...... E-induced replication stress.

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Increased replication initiati ...... E-induced replication stress.

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E Petermann

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P2860

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

Human CtIP promotes DNA end resection

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

Genomic instability--an evolving hallmark of cancer

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

Non-transcriptional control of DNA replication by c-Myc

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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