Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.
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Regulation of glucose homeostasis by GLP-1Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor SystemA Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal StructuresInhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon ReceptorGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesGlucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domainPositive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse ElectrophilesA β-peptide agonist of the GLP-1 receptor, a class B GPCR.Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPERMinireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryPractical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsRecent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.Harnessing allostery: a novel approach to drug discovery.Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1.Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor.Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.What is the potential of G protein-coupled receptor [corrected] allosteric sites in drug design?
P2860
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P2860
Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Small molecule allosteric modu ...... ropic effect of oxyntomodulin.
@en
Small molecule allosteric modu ...... ropic effect of oxyntomodulin.
@nl
type
label
Small molecule allosteric modu ...... ropic effect of oxyntomodulin.
@en
Small molecule allosteric modu ...... ropic effect of oxyntomodulin.
@nl
prefLabel
Small molecule allosteric modu ...... ropic effect of oxyntomodulin.
@en
Small molecule allosteric modu ...... ropic effect of oxyntomodulin.
@nl
P2093
P50
P356
P1476
Small molecule allosteric modu ...... tropic effect of oxyntomodulin
@en
P2093
Aaron D Showalter
Emilia E Savage
Francis S Willard
James Ficorilli
Jorge Alsina-Fernandez
Krister Bokvist
Kyle W Sloop
Thomas B Farb
P304
P356
10.1124/MOL.112.080432
P577
2012-08-28T00:00:00Z