about
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal StructuresThe Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased AgonismKey interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorSulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modificationsGlucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimeticsProlonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.Consequences of splice variation on Secretin family G protein-coupled receptor functionA novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death.Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator.Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172.The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles.Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms.Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.Coding GPCR-G protein specificity.Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.Structure of the adenosine-bound human adenosine A1 receptor–Gi complexExpression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomasTrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus CallosumThe nature of efficacy at G protein-coupled receptorsThe Molecular Control of Calcitonin Receptor SignalingDifferential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled ReceptorsActivation of the GLP-1 receptor by a non-peptidic agonist
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Sebastian George Barton Furness
@ast
Sebastian George Barton Furness
@en
Sebastian George Barton Furness
@es
Sebastian George Barton Furness
@nl
type
label
Sebastian George Barton Furness
@ast
Sebastian George Barton Furness
@en
Sebastian George Barton Furness
@es
Sebastian George Barton Furness
@nl
prefLabel
Sebastian George Barton Furness
@ast
Sebastian George Barton Furness
@en
Sebastian George Barton Furness
@es
Sebastian George Barton Furness
@nl
P106
P1153
17342101700
P31
P496
0000-0001-8655-8221