The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation.
about
Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4ELuzp4 defines a new mRNA export pathway in cancer cellsStructural Basis of Targeting the Exportin CRM1 in CancerMultiple Export Mechanisms for mRNAsPostage for the messenger: designating routes for nuclear mRNA exportIn situ structural analysis of the human nuclear pore complexInvestigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cellsA biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromesRegulation of mRNA trafficking by nuclear pore complexes.RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes.Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3The eIF4E inhibitor ribavirin as a potential antilymphoma therapeutic: early clinical data.Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.The oncogene eIF4E: using biochemical insights to target cancer.Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.Molecular lesions in B-cell lymphoproliferative disorders: recent contributions from studies utilizing high-throughput sequencing techniques.Aiding and abetting cancer: mRNA export and the nuclear pore.Nuclear trafficking in health and disease.Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production.Control of mammalian gene expression by selective mRNA export.Comprehensive analysis of nucleocytoplasmic dynamics of mRNA in Drosophila cells.A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.The eukaryotic translation initiation factor eIF4E wears a "cap" for many occasions.Therapeutic implication of concomitant chromosomal aberrations in patients with aggressive B-cell lymphomasThe eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity.RNA Nuclear Export: From Neurological Disorders to Cancer.Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening.The Impact of Post-transcriptional Control: Better Living Through RNA Regulons
P2860
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P2860
The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@en
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@nl
type
label
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@en
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@nl
prefLabel
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@en
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@nl
P2093
P2860
P1433
P1476
The oncogene eIF4E reprograms ...... and oncogenic transformation.
@en
P2093
Abdellatif Amri
Aurélie Baguet
Biljana Culjkovic-Kraljacic
Katherine L B Borden
Laurent Volpon
P2860
P304
P356
10.1016/J.CELREP.2012.07.007
P577
2012-08-16T00:00:00Z