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Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interactionThe STIM1/Orai signaling machineryAuto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entrySTIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entryLpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cellsCytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload.Cell adhesion on polytetrafluoroethylene modified by UV-irradiation in an ammonia atmosphere.Proliferation of aligned mammalian cells on laser-nanostructured polystyrene.TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survivalNanopatterned polymer substrates promote endothelial proliferation by initiation of β-catenin transcriptional signaling.Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells.Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activationAssembly domains in TRP channels.A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 ChannelsIncreased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutantThe STIM/Orai coupling machinery.Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca(2+)-entryMolecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutantA calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.Recent progress on STIM1 domains controlling Orai activation.Complex role of STIM1 in the activation of store-independent Orai1/3 channels.Cholesterol modulates Orai1 channel functionGating and permeation of Orai channels.Structure, regulation and biophysics of I(CRAC), STIM/Orai1.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Molecular mechanisms of STIM/Orai communication.The STIM1: Orai Interaction.Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.Identification of a rare subset of adipose tissue-resident progenitor cells, which express CD133 and TRPC3 as a VEGF-regulated Ca2+ entry channel.2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.UV surface modification of a new nanocomposite polymer to improve cytocompatibility.Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex.Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christoph Romanin
@ast
Christoph Romanin
@en
Christoph Romanin
@es
Christoph Romanin
@nl
Christoph Romanin
@sl
type
label
Christoph Romanin
@ast
Christoph Romanin
@en
Christoph Romanin
@es
Christoph Romanin
@nl
Christoph Romanin
@sl
prefLabel
Christoph Romanin
@ast
Christoph Romanin
@en
Christoph Romanin
@es
Christoph Romanin
@nl
Christoph Romanin
@sl
P1053
D-5399-2009
P106
P21
P31
P3829
P496
0000-0003-3756-4136