DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

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Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

P2860

Q33726405-91F1A1AC-D9AB-409D-AA65-191C75D24A3D Q38844661-56C88C76-A1F5-4FE0-9AFE-B6D591B96121

P2860

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

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http://www.wikidata.org/entity/Q39334970

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

@zh-cn

2012年学术文章

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2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

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2012年學術文章

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2012年學術文章

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DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

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DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

@nl

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Item

label

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

@en

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

@nl

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DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

@en

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

@nl

P1476

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

@en

P2093

Carol A Miller

http://www.w3.org/2001/XMLSchema#string

Celia Williams

http://www.w3.org/2001/XMLSchema#string

Yi Mo

http://www.w3.org/2001/XMLSchema#string

P2860

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)

IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs

P2888

s12031-012-9782-9

P304

97-110

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P31

scholarly article

P356

10.1007/S12031-012-9782-9

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2012-06-08T00:00:00Z

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P698

22678883

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P921

Alzheimer's disease

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

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P2860

P2860

DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

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P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P577

P698

P921

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P577

P698

P921