Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies. - Wikidata - awgldk - TriplyDB

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

http://www.wikidata.org/entity/Q39345010

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KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.Drugging the addict: non-oncogene addiction as a target for cancer therapy RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?RNAi screening comes of age: improved techniques and complementary approaches Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens.Using immunomic approach to enhance tumor-associated autoantibody detection in diagnosis of hepatocellular carcinoma.RNAi therapies: drugging the undruggable.Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2 Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth.Not just gRASping at flaws: finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers Antitumor activity in RAS-driven tumors by blocking AKT and MEK.RAS transformation requires CUX1-dependent repair of oxidative DNA damage.Drugging the undruggable RAS: Mission possible?Differential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations.Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.Approaches to identifying synthetic lethal interactions in cancer.GATA2 rs2335052 Polymorphism Predicts the Survival of Patients with Colorectal Cancer.Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes.PI3K pathway dependencies in endometrioid endometrial cancer cell lines.Role of apoptosis in colon cancer biology, therapy, and prevention Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer.Systems genetics in "-omics" era: current and future development.Addressing the right targets in oncology: challenges and alternative approaches.KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach.Current views on inducing synthetic lethal RNAi responses in the treatment of cancer.Epistasis in genomic and survival data of cancer patients.A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds Revealing protein networks and gene-drug connectivity in cancer from direct information.Combine and conquer: challenges for targeted therapy combinations in early phase trials.miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3

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P2860

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

http://www.wikidata.org/entity/Q39345010

description

2012 nî lūn-bûn

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Determination of synthetic let ...... rapeutic targeting strategies.

@en

Determination of synthetic let ...... rapeutic targeting strategies.

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type

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Determination of synthetic let ...... rapeutic targeting strategies.

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Determination of synthetic let ...... rapeutic targeting strategies.

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Determination of synthetic let ...... rapeutic targeting strategies.

@en

Determination of synthetic let ...... rapeutic targeting strategies.

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Determination of synthetic let ...... rapeutic targeting strategies.

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Becky Saunders

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David C Hancock

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Hanna Kuznetsov

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Michael Howell

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Michael Steckel

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Michaela Marani

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P2860

STRING: known and predicted protein-protein associations, integrated and transferred across organisms

Cluster analysis and display of genome-wide expression patterns

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.

Creation of human tumour cells with defined genetic elements

Targeting RAS signalling pathways in cancer therapy

An early haematopoietic defect in mice lacking the transcription factor GATA-2

Principles of cancer therapy: oncogene and non-oncogene addiction

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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1227-1245

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scholarly article

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10.1038/CR.2012.82

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8

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22

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Julian Downward

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2012-05-22T00:00:00Z

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225053160

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22613949

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3411175

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