Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
about
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survivalBiochemical effects of SIRT1 activatorsHormonal control of androgen receptor function through SIRT1Sirtuin 1 and sirtuin 3: physiological modulators of metabolismStructural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 EnzymesCrystal structure of the yeast nicotinamidase Pnc1pStructural Insights into Intermediate Steps in the Sir2 Deacetylation ReactionHigh-Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into the Catalytic Mechanism and Inhibition by Aldehydes,A Molecular Mechanism for Direct Sirtuin Activation by ResveratrolIdentification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.The forkhead transcription factor Hcm1 promotes mitochondrial biogenesis and stress resistance in yeast.Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanismNAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicityBiochemical and mutational analysis of a novel nicotinamidase from Oceanobacillus iheyensis HTE831Synthesis and Assay of SIRT1-Activating CompoundsMammalian sirtuins: biological insights and disease relevanceThe Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populationsRole of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.Calorie restriction effects on silencing and recombination at the yeast rDNA.A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Small-molecule allosteric activators of sirtuins.Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in miceSirtuin chemical mechanismsNicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasmaNeuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activationMechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studiesStructural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrolSirtuin modulators.Ageing and metabolism: drug discovery opportunities.Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues.Single sample extraction protocol for the quantification of NAD and NADH redox states in Saccharomyces cerevisiae.Genome-health nutrigenomics and nutrigenetics: nutritional requirements or 'nutriomes' for chromosomal stability and telomere maintenance at the individual level.Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.Sirtuin deacetylases as therapeutic targets in the nervous systemNicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans.Sirtuin inhibitors.
P2860
Q24612868-25D08A35-4EFA-4116-B442-4000ECF8A161Q24633830-B9CDBD62-9B73-46D2-B82A-C1787F8CF21DQ24672448-2E5D88D4-93A7-4846-B338-43C906F16A27Q26828607-77FD5E9B-42C4-4900-9B44-B4649098DE04Q27643772-AD1E89C0-93ED-44BB-BF47-CAF76AB7CCE9Q27644216-9C5AC8B9-11EA-4674-AFFA-51AC1D513A9BQ27652097-5B3CEE88-7072-44C1-B034-8C1EC5E54288Q27664600-44C46355-5628-4FF2-BB75-FDD2C74D4AE5Q27675270-EEC7F7FE-A5B4-4071-9ADF-600E8954A7F5Q27932210-F55F5F6B-95AF-410D-8236-150CAC32413DQ27932823-E7D1705E-3B8C-424F-BBFE-3D6008883344Q27937936-493F56B9-B637-4DB3-9A84-042F55568EB3Q28383252-B93CAE11-BDC2-435D-AF23-38311799FFAEQ28476267-63F73846-BA99-4850-9FC0-C9A1819F6CABQ28486735-21E18E95-BFB6-4F86-A5A1-2235C6FEB2A9Q28818352-C36B477C-9F97-4F80-9296-E224DF4A9AD0Q29614496-5350FDEB-4C96-4399-974F-98DDBFE998ACQ30276142-E0496753-0DBC-469E-BE06-AFD267BF6362Q30300373-447B3E8F-6038-4BFC-B1E6-2FE05407CFE1Q30386186-15501F8C-FD76-493A-8A17-AE8D93A0490CQ30418777-B50577DA-DDB8-4139-90B3-59786595C444Q30430955-6A23AFBA-4EBE-47D5-ABD9-8B63E51AF0F2Q30578694-FA4542D5-B20A-4064-846C-465AC71C9993Q33601236-4B66C4A3-70E4-4C8E-B0DB-68E03957F9F3Q33855851-A152881C-EDBC-48A6-B9E8-FB0311794911Q33915481-CF917FA3-5294-4B9B-BFDF-6F229E5F41CDQ33985992-1418A4CF-1D7C-46E5-9CAF-32B841998D19Q34534198-B789B6EC-BEA6-4517-A0AD-E3167BECB637Q34911412-7209DA22-CD1F-4C1E-85F0-D05786DFD2F1Q35252505-3121D4C3-4579-4F92-A1BB-CF502E37267CQ35830011-B8871DC6-0B2B-4BBF-A69C-1C8DFB334552Q36165220-941813FF-01C5-4433-900B-43DC1CDEF1ADQ36174012-21A56030-7E70-4E70-AE82-D5B3BA28F019Q37024437-5A9DE309-4643-494A-8249-134D036E04B4Q37092531-401F7D37-E081-46C0-8626-AE129C752748Q37138644-9816975F-2518-4041-8AC7-9DEE177EACBEQ37180789-CDEFBCA1-4B24-44F7-848E-903F61F0E1B2Q37249172-EDA82B18-EE2E-41A8-84CA-6040BF8A1B1BQ37385509-D09A1878-FF67-46B2-AEE9-2B7887CE8BD5Q37481259-5A97704A-BD74-4DEE-ACD4-C072F6B9F51C
P2860
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@en
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@nl
type
label
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@en
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@nl
prefLabel
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@en
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@nl
P2093
P1433
P1476
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
@en
P2093
Anthony A Sauve
Ian M Willis
Robyn D Moir
Vern L Schramm
P304
P356
10.1016/J.MOLCEL.2004.12.032
P577
2005-02-01T00:00:00Z