Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.
about
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choiceReactivity of Nucleic Acid Radicals.Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - when is a DSB not a DSB?Delayed repair of radiation induced clustered DNA damage: friend or foe?Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell cultureRestriction-modification system with methyl-inhibited base excision and abasic-site cleavage activitiesDouble-strand breaks from a radical commonly produced by DNA-damaging agents.Disruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesionsEffects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB induction and conversion induced by gamma rays and helium ions.Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human GenomeMechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular DamageEfficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1.Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clustersCorrelation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion.Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A.5,6-Dihydropyrimidine peroxyl radical reactivity in DNA.Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response.Radiation-mediated formation of complex damage to DNA: a chemical aspect overview.Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.DNA damage of glioblastoma multiform cells induced by Beta radiation of iodine-131 in the presence or absence of topotecan: a picogreen and colonogenic assayNucleotide excision repair of chemically stabilized analogues of DNA interstrand cross-links produced from oxidized abasic sites.Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles.Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation.Enhanced Cleavage at Abasic Sites within Clustered Lesions in Nucleosome Core Particles
P2860
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P2860
Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@en
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@nl
type
label
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@en
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@nl
prefLabel
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@en
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@nl
P2093
P2860
P356
P1476
Hierarchy of lesion processing ...... e-lesion clustered DNA damage.
@en
P2093
Laura J Eccles
Martine E Lomax
Peter O'Neill
P2860
P304
P356
10.1093/NAR/GKP1070
P407
P577
2009-12-03T00:00:00Z