Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. - Wikidata - awgldk - TriplyDB

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.

http://www.wikidata.org/entity/Q39388766

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Histone methyltransferases: novel targets for tumor and developmental defects Metabolic modulation of chromatin: implications for DNA repair and genomic integrity Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle Msl2 is a novel component of the vertebrate DNA damage response DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy Histone methylation and aging: lessons learned from model systems.Interpreting the Epstein-Barr Virus (EBV) epigenome using high-throughput data A PHF8 homolog in C. elegans promotes DNA repair via homologous recombination.Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168 The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.PHRF1 promotes genome integrity by modulating non-homologous end-joining.Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells Targeting the epigenetics of the DNA damage response in breast cancer.A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer.BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD BAG6/BAT3: emerging roles in quality control for nascent polypeptides.Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence.BAG-6, a jack of all trades in health and disease.Chromatin modifications and DNA repair: beyond double-strand breaks.Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.The upstreams and downstreams of H3K79 methylation by DOT1L.Histone modifications in DNA damage response.Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.The nucleosome: orchestrating DNA damage signaling and repair within chromatin.DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro.A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage.Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.Aging as an Epigenetic Phenomenon.DOT1L and H3K79 Methylation in Transcription and Genomic Stability.

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Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.

http://www.wikidata.org/entity/Q39388766

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@en

Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@nl

type

label

Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@en

Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@nl

prefLabel

Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@en

Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@nl

P1433

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P1433

The EMBO Journal

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Bat3 facilitates H3K79 dimethy ...... ci at G1/G2 cell-cycle phases.

@en

P2093

Junjie Feng

http://www.w3.org/2001/XMLSchema#string

Qinhong Wang

http://www.w3.org/2001/XMLSchema#string

Timothy P Wakeman

http://www.w3.org/2001/XMLSchema#string

Xiao-Fan Wang

http://www.w3.org/2001/XMLSchema#string

P2860

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53

BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression

A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

hDOT1L links histone methylation to leukemogenesis.

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

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2169-2181

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scholarly article

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10.1038/EMBOJ.2012.50

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9

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31

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2012-02-28T00:00:00Z

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221869586

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22373577

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3343460

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